RNF6 抗体 (AA 470-550)
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Quick Overview for RNF6 抗体 (AA 470-550) (ABIN7231114)
抗原
See all RNF6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 470-550
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原理
- Rabbit Anti-RNF6 Polyclonal Antibody
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特异性
- The antibody detects endogenous levels of RNF6 protein
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthesized peptide derived from part region of human RNF6 protein at AA range: 470-550
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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有效期
- 12 months
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- RNF6 (RING Finger Protein 6 (RNF6))
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别名
- RNF6
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背景
- E3 ubiquitin-protein ligase RNF6, RING-type E3 ubiquitin transferase RNF6RNF6 (Ring Finger Protein 6) is a Protein Coding gene. Diseases associated with RNF6 include Esophageal Cancer and Squamous Cell Carcinoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Androgen receptor signaling pathway. The protein encoded by RNF6 contains a RING-H2 finger motif. Deletions and mutations in RNF6 were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed.
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分子量
- 75kD
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基因ID
- 6049
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UniProt
- Q9Y252
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Cell Size
抗原
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