RAP1GAP 抗体 (AA 460-540)
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Quick Overview for RAP1GAP 抗体 (AA 460-540) (ABIN7216788)
抗原
See all RAP1GAP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 460-540
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原理
- Rap1GAP Polyclonal Antibody
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特异性
- Rap1GAP Polyclonal Antibody detects endogenous levels of Rap1GAP protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from the C-terminal region of human Rap1GAP at AA range: 460-540
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:10000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- RAP1GAP (RAP1 GTPase Activating Protein (RAP1GAP))
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别名
- Rap1GAP
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背景
- Rabbit Anti-Rap1GAP Polyclonal Antibody,RAP1GAP, KIAA0474, RAP1GA1, Rap1 GTPase-activating protein 1, Rap1GAP, Rap1GAP1,RAP1GAP encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins.,Rap1 GTPase-activating protein 1
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分子量
- observerd band 73kDa
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基因ID
- 5909
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UniProt
- P47736
抗原
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