RAPGEF3 抗体 (AA 690-770)
Our Local Distributor
北京 101111
Quick Overview for RAPGEF3 抗体 (AA 690-770) (ABIN7218978)
抗原
See all RAPGEF3 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 690-770
-
原理
- Epac Polyclonal Antibody
-
特异性
- Epac Polyclonal Antibody detects endogenous levels of Epac protein.
-
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
-
免疫原
- Synthesized peptide derived from the C-terminal region of human Epac at AA range: 690-770
-
亚型
- IgG
-
-
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) (AA 1-881) antibody
RAPGEF3 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) (AA 1-200) antibodyRAPGEF3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) (C-Term) antibodyRAPGEF3 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) (AA 772-881) antibodyRAPGEF3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2E5 unconjugated
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) (AA 301-400) antibodyRAPGEF3 适用: 人, 大鼠 ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) antibodyRAPGEF3 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB5060 unconjugated Recombinant Antibody
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) (AA 772-881) antibodyRAPGEF3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) (C-Term) antibodyRAPGEF3 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) (AA 359-408) antibodyRAPGEF3 适用: 人, 小鼠, 大鼠, 马, Cow, 犬, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) (AA 107-156) antibodyRAPGEF3 适用: 人, 小鼠, 大鼠, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.
-
说明
-
Primary Antibody
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
-
-
- RAPGEF3 (Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3))
-
别名
- Epac
-
背景
- Rabbit Anti-Epac Polyclonal Antibody,RAPGEF3, CGEF1, EPAC, EPAC1, Rap guanine nucleotide exchange factor 3, Exchange factor directly activated by cAMP 1, Exchange protein directly activated by cAMP 1, EPAC 1, Rap1 guanine-nucleotide-exchange factor directly activated by cAMP,RAPGEF3 (Rap Guanine Nucleotide Exchange Factor 3) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and cAMP-dependent protein kinase regulator activity. An important paralog of this gene is RASGEF1A. uanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. TPases are a group of enzymes that catalyze hydrolysis of the gamma phosphate bond in guanine triphosphate (GTP) to form guanine diphosphate (GDP). Mg2+ ions are essential for catalytic activity. GTPases, often coupled to G proteins, are essential in signal transduction.,Rap guanine nucleotide exchange factor 3
-
分子量
- observerd band 100kDa
-
基因ID
- 10411
-
UniProt
- O95398
-
途径
- cAMP Metabolic Process
抗原
-
