Phosducin-Like 抗体
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Quick Overview for Phosducin-Like 抗体 (ABIN7230624)
抗原
See all Phosducin-Like (PDCL) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- PHLP1 Polyclonal Antibody
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特异性
- The antibody detects endogenous levels of PHLP1 protein
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen
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免疫原
- Synthesized peptide derived from part region of human PHLP1 protein
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亚型
- IgG
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anti-Phosducin-Like (PDCL) antibody
PDCL 适用: 人 WB, IHC (p), ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Phosducin-Like (PDCL) (AA 1-301) antibodyPDCL 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4G5 unconjugated
anti-Phosducin-Like (PDCL) (AA 51-150) antibodyPDCL 适用: 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Phosducin-Like (PDCL) antibodyPDCL 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Phosducin-Like (PDCL) (AA 1-30), (N-Term) antibodyPDCL 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB46970 unconjugated
anti-Phosducin-Like (PDCL) antibodyPDCL 适用: Timothy grass (Phleum pratense) WB, ELISA, DB 宿主: 兔 Chimeric 25 unconjugated Recombinant Antibody
anti-Phosducin-Like (PDCL) antibodyPDCL 适用: Timothy grass (Phleum pratense) WB, ELISA, DB 宿主: Human Monoclonal 25 unconjugated Recombinant Antibody
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- Phosducin-Like (PDCL)
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别名
- PHLP1
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背景
- Rabbit Anti-PHLP1 Polyclonal Antibody,PH domain leucine-rich repeat-containing protein phosphatase 1, Pleckstrin homology domain-containing family E member 1, PH domain-containing family E member 1, Suprachiasmatic nucleus circadian oscillatory protein, hSCOP,Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family, specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed: 15808505, PubMed: 17386267, PubMed: 18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed: 18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed: 20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed: 21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed: 19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed: 24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity).,PHLP1
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分子量
- observerd band 188kDa
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基因ID
- 23239
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UniProt
- O60346
抗原
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