Phosducin-Like 抗体
Quick Overview for Phosducin-Like 抗体 (ABIN7230624)
抗原
See all Phosducin-Like (PDCL) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- PHLP1 Polyclonal Antibody
-
特异性
- The antibody detects endogenous levels of PHLP1 protein
-
纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen
-
免疫原
- Synthesized peptide derived from part region of human PHLP1 protein
-
亚型
- IgG
-
-
anti-Phosducin-Like (PDCL) antibody
PDCL 适用: 人 WB, IHC (p), ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Phosducin-Like (PDCL) (AA 1-301) antibodyPDCL 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4G5 unconjugated
anti-Phosducin-Like (PDCL) (AA 51-150) antibodyPDCL 适用: 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Phosducin-Like (PDCL) antibodyPDCL 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Phosducin-Like (PDCL) (AA 1-30), (N-Term) antibodyPDCL 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB46970 unconjugated
anti-Phosducin-Like (PDCL) antibodyPDCL 适用: Timothy grass (Phleum pratense) WB, ELISA, DB 宿主: 兔 Chimeric 25 unconjugated Recombinant Antibody
anti-Phosducin-Like (PDCL) antibodyPDCL 适用: Timothy grass (Phleum pratense) WB, ELISA, DB 宿主: Human Monoclonal 25 unconjugated Recombinant Antibody
-
-
应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).
-
说明
-
Primary Antibody
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
-
-
- Phosducin-Like (PDCL)
-
别名
- PHLP1
-
背景
- Rabbit Anti-PHLP1 Polyclonal Antibody,PH domain leucine-rich repeat-containing protein phosphatase 1, Pleckstrin homology domain-containing family E member 1, PH domain-containing family E member 1, Suprachiasmatic nucleus circadian oscillatory protein, hSCOP,Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family, specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed: 15808505, PubMed: 17386267, PubMed: 18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed: 18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed: 20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed: 21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed: 19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed: 24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity).,PHLP1
-
分子量
- observerd band 188kDa
-
基因ID
- 23239
-
UniProt
- O60346
抗原
-
