P35 (AA 30-110) 抗体
This 兔 多克隆 anti-not_set antibody specifically detects not_set in WB, ELISA, IF 和 IHC (p). The antibody is reactive with 人, 小鼠 和 大鼠 samples.
产品编号 ABIN7216376
发货至:
中国
Contact our Customer Service for availability and price in your country.
Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for P35 (AA 30-110) 抗体 (ABIN7216376)
抗原
P35
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
非结合性
应用范围
Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
-
-
抗原表位
- AA 30-110
-
原理
- p35 Polyclonal Antibody
-
特异性
- P35 Polyclonal Antibody detects endogenous levels of p35 protein.
-
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
-
免疫原
- Synthesized peptide derived from the N-terminal region of human p35 at AA range: 30-110
-
亚型
- IgG
-
-
anti-P35 (N-Term) antibody
适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-P35 antibody适用: Borrelia burgdorferi WB, ELISA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:20000). Not yet tested in other applications.
-
说明
-
Primary Antibody
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
-
-
- P35
-
物质类
- Viral Protein
-
背景
- Rabbit Anti-p35 Polyclonal Antibody,CDK5R1, CDK5R, NCK5A, Cyclin-dependent kinase 5 activator 1, CDK5 activator 1, Cyclin-dependent kinase 5 regulatory subunit 1, TPKII regulatory subunit,Cyclin dependent kinase 5 regulatory subunit 1 encoded by CDK5R1 (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5), the activation of CDK5 is required for proper development of the central nervous system. The p35 form of cyclin dependent kinase 5 regulatory subunit 1 is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.,Cyclin-dependent kinase 5 activator 1
-
分子量
- observerd band 38kDa
-
基因ID
- 8851
-
UniProt
- Q15078
抗原
-
You are here:
