NOLC1 抗体
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北京 101111
Quick Overview for NOLC1 抗体 (ABIN7223956)
抗原
See all NOLC1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- p130 Polyclonal Antibody
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特异性
- P130 Polyclonal Antibody detects endogenous levels of p130 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from human p130 around the non-phosphorylation site of S952
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亚型
- IgG
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anti-Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1) (AA 590-699) antibody
NOLC1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 6B4 unconjugated
anti-Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1) (C-Term) antibodyNOLC1 适用: 人, 小鼠, 大鼠, 犬, Drosophila melanogaster, Arabidopsis WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1) (C-Term) antibodyNOLC1 适用: 人, 小鼠, 大鼠, Cow, 兔, 豚鼠, 犬, 山羊, 马, 斑马鱼, Saccharomyces cerevisiae WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1) antibodyNOLC1 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 24GB490 unconjugated Recombinant Antibody
anti-Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1) (AA 590-699) antibodyNOLC1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F8 unconjugated
anti-Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1) (AA 400-699) antibodyNOLC1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1) (C-Term) antibodyNOLC1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1) antibodyNOLC1 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1) (pThr986) antibodyKD Validated NOLC1 适用: 人 WB 宿主: 兔 Monoclonal 25GB7985 unconjugated Recombinant Antibody
anti-Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1) (AA 1-700) antibodyNOLC1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF (1:200-1:1000), ELISA (1:5000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- NOLC1 (Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1))
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别名
- p130
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背景
- Rabbit Anti-p130 Polyclonal Antibody,RBL2, RB2, Retinoblastoma-like protein 2, 130 kDa retinoblastoma-associated protein, p130, Retinoblastoma-related protein 2, RBR-2, pRb2,The retinoblastoma (Rb) tumor suppressor family includes the retinoblastoma protein Rb (p105), retinoblastoma-like protein 1 (RBL1, p107), and retinoblastoma-like protein 2 (RBL2, p130). These Rb family proteins are referred to as 'pocket proteins' because they contain a conserved binding pocket region that interacts with critical regulatory proteins, including E2F family transcription factors, c-Abl tyrosine kinase, and proteins containing a conserved LXCXE motif. In quiescent G0 phase cells, active Rb proteins are hypophosphorylated and bind to E2F transcription factors to repress transcription and inhibit cell cycle progression. Upon growth factor induction of quiescent cells, Rb proteins become hyperphosphorylated and inactivated by G1-phase cyclinD-cdk4/6, G1/S-phase cyclin E-cdk2, and G1/S-phase cyclin A-cdk2 complexes. Hyperphosphorylation of Rb proteins results in a loss of E2F binding and allows for transcriptional activation and cell cycle progression. In addition to regulating the cell cycle, Rb proteins regulate chromosome stability, induction, and maintenance of senescence, apoptosis, cellular differentiation, and angiogenesis. Retinoblastoma-like protein 2 (RBL2, p130) is the most predominant and active Rb family member found in quiescent cells. In these cells, RBL2 interacts with E2F4 and E2F5 to recruit the DP, RB-like, E2F, and MuvB protein (DREAM) complex to E2F target genes to repress transcription of multiple genes required for progression into S phase and mitosis. Hypophosphorylation of RBL2 during cellular senescence is required for maintenance of senescent cells.,Retinoblastoma-like protein 2
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基因ID
- 5934
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UniProt
- Q08999
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途径
- Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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