MAPK8IP1 抗体 (pThr103)
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北京 101111
Quick Overview for MAPK8IP1 抗体 (pThr103) (ABIN7225994)
抗原
See all MAPK8IP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pThr103
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原理
- Rabbit Anti-JIP-1 (phospho Thr103) Polyclonal Antibody
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特异性
- Phospho-JIP-1 (T103) Polyclonal Antibody detects endogenous levels of JIP-1 protein only when phosphorylated at T103.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthesized peptide derived from human JIP-1 Phospho-Thr103
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亚型
- IgG
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anti-Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) antibody
MAPK8IP1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) (AA 470-498), (C-Term) antibodyMAPK8IP1 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB23000 unconjugated
anti-Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) (Tyr466) antibodyMAPK8IP1 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) (AA 69-118) antibodyMAPK8IP1 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) antibodyMAPK8IP1 适用: 人 WB, IHC, FACS, IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) (AA 425-524) antibodyMAPK8IP1 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) (AA 265-279) antibodyVerified MAPK8IP1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) (AA 470-498) antibodyMAPK8IP1 适用: 人 WB, IF, IHC, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) (pThr103) antibodyMAPK8IP1 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) (pThr103) antibodyMAPK8IP1 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:5000,Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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有效期
- 12 months
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- MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1))
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别名
- JIP-1
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背景
- MAPK8IP1, IB1, JIP1, PRKM8IP, C-Jun-amino-terminal kinase-interacting protein 1, JIP-1, JNK-interacting protein 1, Islet-brain 1, IB-1, JNK MAP kinase scaffold protein 1, Mitogen-activated protein kinase 8-interacting protein 1MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1) encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. MAPK8IP1 is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
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分子量
- 113kD
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基因ID
- 9479
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UniProt
- Q9UQF2
抗原
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