LIMK-1/2 抗体
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北京 101111
Quick Overview for LIMK-1/2 抗体 (ABIN7215608)
抗原
适用
宿主
克隆类型
标记
应用范围
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原理
- LIMK-1/2 Polyclonal Antibody
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特异性
- LIMK-1/2 Polyclonal Antibody detects endogenous levels of LIMK-1/2 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from human LIMK-1/2 around the non-phosphorylation site of T508/505
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亚型
- IgG
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anti-LIMK-1/2 (pThr505), (pThr508) antibody
适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-LIMK-1/2 (Ser104) antibody适用: 人, 大鼠, 小鼠, 猴 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-LIMK-1/2 (C-Term), (pSer505), (pSer508) antibody适用: 人, 大鼠, 小鸡, Cow WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-LIMK-1/2 (pThr505), (pThr508) antibody适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-LIMK-1/2 (AA 481-530) antibody适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-LIMK-1/2 (C-Term) antibody适用: 人, 大鼠, 小鼠, 小鸡, Cow WB, IP 宿主: 兔 Polyclonal unconjugated
anti-LIMK-1/2 (C-Term), (pSer505), (pSer508) antibody适用: 人, 大鼠, 小鼠, 小鸡, Cow WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:40000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- LIMK-1/2
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背景
- Rabbit Anti-LIMK-1/2 Polyclonal Antibody,LIMK1, LIMK, LIM domain kinase 1, LIMK-1, LIMK2, LIM domain kinase 2, LIMK-2,There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. LIM domain kinase 1 is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. LIM domain kinase 1 also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,LIM domain kinase 1
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分子量
- observerd band 72kDa
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基因ID
- 3984, 3985
抗原
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