LATS1,2 (pThr1041), (pThr1079) 抗体
This 兔 多克隆 anti-not_set antibody specifically detects not_set in ELISA 和 IHC (p). The antibody is reactive with 人 和 小鼠 samples.
产品编号 ABIN7225824
发货至:
中国
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Contact Info
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中国
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北京 101111
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Quick Overview for LATS1,2 (pThr1041), (pThr1079) 抗体 (ABIN7225824)
抗原
LATS1,2
适用
人, 小鼠
宿主
兔
克隆类型
多克隆
标记
非结合性
应用范围
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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抗原表位
- pThr1041, pThr1079
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原理
- LATS1/2 (phospho Thr1079/1041) Polyclonal Antibody
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特异性
- Phospho-LATS1/2 (T1079/1041) Polyclonal Antibody detects endogenous levels of LATS1/2 protein only when phosphorylated at T1079/1041.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from human LATS1/2 Phospho-Thr1079/1041
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亚型
- IgG
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anti-LATS1,2 (AA 641-740) antibody
适用: 人, 小鼠, 大鼠 ELISA, WB, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-LATS1,2 (Ser116) antibody适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- LATS1,2
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别名
- LATS1/2
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背景
- Rabbit Anti-LATS1/2 (phospho Thr1079/1041) Polyclonal Antibody,LATS1, WARTS, Serine/threonine-protein kinase LATS1, Large tumor suppressor homolog 1, WARTS protein kinase, h-warts, LATS2, KPM, Serine/threonine-protein kinase LATS2, Kinase phosphorylated during mitosis protein, Large tumor suppressor ho,The protein encoded by LATS1 (large tumor suppressor kinase 1) is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for LATS1.,serine threonine-protein kinase LATS1
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基因ID
- 9113, 26524
抗原
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