JAK2/3 抗体 (pTyr939, pTyr966)
This 兔 多克隆 anti-JAK2/3 antibody specifically detects JAK2/3 in WB 和 ICC. The antibody is reactive with 人, 小鼠 和 大鼠 samples.
产品编号 ABIN7229208
发货至:
中国
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Quick Overview for JAK2/3 抗体 (pTyr939, pTyr966) (ABIN7229208)
抗原
JAK2/3
(Janus Kinase 2/3 (JAK2/3))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This JAK2/3 antibody is un-conjugated
应用范围
Western Blotting (WB), Immunocytochemistry (ICC)
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抗原表位
- pTyr939, pTyr966
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原理
- JAK2/3 (Phospho-Tyr966/939) Polyclonal Antibody
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特异性
- The antibody detects endogenous levels of JAK2/3 when Phospho occurs at Tyr966/939(human) or Tyr966/935(mouse/rat) , It doesn't react with total protein.
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen
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免疫原
- Synthesized peptide derived from part region of human JAK2/3 (Phospho-Tyr966/939) Antibody protein at AA range: T966
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:1000), ICC (1:200). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol as stabilizer.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- JAK2/3 (Janus Kinase 2/3 (JAK2/3))
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别名
- JAK2/3
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背景
- Rabbit Anti-JAK2/3 (Phospho-Tyr966/939) Polyclonal Antibody,Tyrosine-protein kinase JAK2/JAK3, Janus kinase 2/Janus kinase 3, JAK-2/JAK-3,JAK2 is a kinase that is misregulated or mutated in a number of myeloproliferative diseases and cancers. The mutation V617F is the most clinically relevant variant, and is seen in around half of myeloproliferative disorders. The variant is a known activating mutation, and activated JAK2 is sufficient to drive myeloproliferative disorders in mouse models. V617F, while most recurrent, is not the only mechanism by which JAK2 can be activated in patients. JAK2 is now one of the first diagnostic markers tested upon diagnosis with a myeloproliferative disorder.,JAK2/3
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基因ID
- 1132, 1124
抗原
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