SH3KBP1 抗体 (AA 591-665) (Cy7)
Quick Overview for SH3KBP1 抗体 (AA 591-665) (Cy7) (ABIN716222)
抗原
See all SH3KBP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 591-665
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预测反应
- Human,Mouse,Rat,Cow,Sheep,Chicken,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human SH3KBP1
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亚型
- IgG
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anti-SH3-Domain Kinase Binding Protein 1 (SH3KBP1) (N-Term) antibody
SH3KBP1 适用: 人, 大鼠, 小鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-SH3-Domain Kinase Binding Protein 1 (SH3KBP1) antibodySH3KBP1 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SH3-Domain Kinase Binding Protein 1 (SH3KBP1) (AA 224-308) antibodySH3KBP1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F11 unconjugated
anti-SH3-Domain Kinase Binding Protein 1 (SH3KBP1) (AA 1-665) antibodySH3KBP1 适用: 人 WB, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-SH3-Domain Kinase Binding Protein 1 (SH3KBP1) (AA 107-156) antibodySH3KBP1 适用: 人, 大鼠, 小鼠, 兔, Cow, 犬, 豚鼠, 马, Bat, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-SH3-Domain Kinase Binding Protein 1 (SH3KBP1) (N-Term) antibodySH3KBP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-SH3-Domain Kinase Binding Protein 1 (SH3KBP1) (N-Term) antibodySH3KBP1 适用: 人, 大鼠, 小鼠, 兔, Cow, 犬, 豚鼠, 马, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- SH3KBP1 (SH3-Domain Kinase Binding Protein 1 (SH3KBP1))
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别名
- SH3KBP1
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背景
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Synonyms: Cbl interacting protein, Cbl interacting protein of 85 kDa, CD2 binding protein 3, CD2BP3, CIN 85, CIN85, GIG 10, GIG10, HSB 1, Human Src family kinase binding protein 1, MIG 18, MIG18, Migration inducing gene 18 protein, SH3 domain kinase binding protein 1, SH3BP 1, Src family kinase binding protein 1, src related kinase binding protein 1, SH3K1_HUMAN.
Background: SH3KBP1 belongs to the CIN85/CMS family of adaptor molecules, characterized by containing three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The different members of the family orchestrate a network involved in dowregulation and degradation of recpetor tyrosine kinases. SH3KBP1 is involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. In the case of EGF receptor turnover, its activation involves recruitment of SH3KBP1- endophilin complexes to mediate internalization. Once internalized, RTKs are delivered into the endosomal compartment where receptors get sorted for either recycling back to the cell surface or are targeted to lysosomes for degradation. Alternate splicing results in multiple transcript variants.
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基因ID
- 30011
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途径
- EGFR Signaling Pathway, EGFR Downregulation
抗原
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