IBTK 抗体 (AA 410-490)
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北京 101111
Quick Overview for IBTK 抗体 (AA 410-490) (ABIN7229004)
抗原
See all IBTK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 410-490
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原理
- Rabbit Anti-IBTK Polyclonal Antibody
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特异性
- The antibody detects endogenous levels of IBTK protein
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthesized peptide derived from part region of human IBTK protein at AA range: 410-490
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亚型
- IgG
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anti-Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK) (AA 589-617), (Middle Region) antibody
IBTK 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK) (AA 586-613) antibodyIBTK 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB24652 unconjugated
anti-Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK) (AA 1-1353) antibodyIBTK 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK) (AA 900-1200) antibodyIBTK 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK) (C-Term) antibodyIBTK 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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有效期
- 12 months
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- IBTK (Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))
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别名
- IBTK
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背景
- Inhibitor of Bruton tyrosine kinase, IBtkIBTK (Inhibitor Of Bruton Tyrosine Kinase) is a Protein Coding gene. Diseases associated with IBTK include Agammaglobulinemia. Among its related pathways are B cell receptor signaling pathway (KEGG). Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by IBTK binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. IBTK has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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分子量
- 148kD
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基因ID
- 25998
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UniProt
- Q9P2D0
抗原
-
