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HIRA 抗体 (pThr555)

This 兔 多克隆 anti-HIRA antibody specifically detects HIRA in ELISA, IF 和 IHC (p). The antibody is reactive with 人 和 小鼠 samples.
产品编号 ABIN7224840
发货至: 中国
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中国
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
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Quick Overview for HIRA 抗体 (pThr555) (ABIN7224840)

抗原

See all HIRA 抗体
HIRA (HIR Histone Cell Cycle Regulation Defective Homolog A (HIRA))

适用

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人, 小鼠

宿主

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克隆类型

  • 46
  • 20
多克隆

标记

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This HIRA antibody is un-conjugated

应用范围

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ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

    • 15
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    • 1
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    pThr555

    原理

    HIRA (phospho Thr555) Polyclonal Antibody

    特异性

    Phospho-HIRA (T555) Polyclonal Antibody detects endogenous levels of HIRA protein only when phosphorylated at T555.

    纯化方法

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

    免疫原

    Synthesized peptide derived from human HIRA Phospho-Thr555

    亚型

    IgG
  • 应用备注

    Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:10000). Not yet tested in other applications.

    说明

    Primary Antibody

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
  • 抗原

    HIRA (HIR Histone Cell Cycle Regulation Defective Homolog A (HIRA))

    别名

    HIRA

    背景

    Rabbit Anti-HIRA (phospho Thr555) Polyclonal Antibody,HIRA, DGCR1, HIR, TUPLE1, Protein HIRA, TUP1-like enhancer of split protein 1,HIRA (histone cell cycle regulator) encodes a histone chaperone that preferentially places the variant histone H3. in nucleosomes. Orthologs of HIRA in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.,Protein HIRA

    基因ID

    7290

    UniProt

    P54198

    途径

    Chromatin Binding
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