GRIA4 抗体 (pSer862)
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Quick Overview for GRIA4 抗体 (pSer862) (ABIN7221300)
抗原
See all GRIA4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer862
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原理
- GluR4 (phospho Ser862) Polyclonal Antibody
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特异性
- Phospho-GluR4 (S862) Polyclonal Antibody detects endogenous levels of GluR4 protein only when phosphorylated at S862.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from human GluR4 Phospho-Ser862
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:5000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- GRIA4 (Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4))
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别名
- GluR4
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背景
- Rabbit Anti-GluR4 (phospho Ser862) Polyclonal Antibody,GRIA4, GLUR4, Glutamate receptor 4, GluR-4, GluR4, AMPA-selective glutamate receptor 4, GluR-D, Glutamate receptor ionotropic, AMPA 4, GluA4,Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by GRIA4 belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA, R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of GRIA4 show a positive association with schizophrenia.,Glutamate receptor 4
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分子量
- observerd band 100kDa
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基因ID
- 2893
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UniProt
- P48058
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途径
- PI3K-Akt Signaling
抗原
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