GPR144 抗体 (AA 60-140)
This 兔 多克隆 anti-GPR144 antibody specifically detects GPR144 in WB, ELISA 和 IF. The antibody is reactive with 人 samples.
产品编号 ABIN7221698
发货至:
中国
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Quick Overview for GPR144 抗体 (AA 60-140) (ABIN7221698)
抗原
See all GPR144 抗体
GPR144
(G Protein-Coupled Receptor 144 (GPR144))
适用
人
宿主
兔
克隆类型
多克隆
标记
This GPR144 antibody is un-conjugated
应用范围
Western Blotting (WB), ELISA, Immunofluorescence (IF)
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抗原表位
- AA 60-140
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原理
- GPR144 Polyclonal Antibody
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特异性
- GPR144 Polyclonal Antibody detects endogenous levels of GPR144 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from the N-terminal region of human GPR144 at AA range: 60-140
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亚型
- IgG
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anti-G Protein-Coupled Receptor 144 (GPR144) antibody
GPR144 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 144 (GPR144) (AA 342-370) antibodyGPR144 适用: 人 WB 宿主: 兔 Polyclonal RB28245 unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IF (1:200-1:1000), ELISA (1:5000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- GPR144 (G Protein-Coupled Receptor 144 (GPR144))
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别名
- GPR144
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背景
- Rabbit Anti-GPR144 Polyclonal Antibody,GPR144, PGR24, Probable G-protein coupled receptor 144, G-protein coupled receptor PGR24,G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells.,Probable G-protein coupled receptor 144
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分子量
- observerd band 104kDa
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基因ID
- 347088
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UniProt
- Q7Z7M1
抗原
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