Factor 12 Heavy Chain (F12) (AA 10-90), (Cleaved-Ile20) 抗体
This 兔 多克隆 antibody specifically detects Factor 12 Heavy Chain in WB, ELISA 和 IHC (p). It exhibits reactivity toward 人.
产品编号 ABIN7220412
发货至:
中国
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Quick Overview for Factor 12 Heavy Chain (F12) (AA 10-90), (Cleaved-Ile20) 抗体 (ABIN7220412)
抗原
See all Factor 12 Heavy Chain (F12) 抗体
Factor 12 Heavy Chain (F12)
适用
人
宿主
兔
克隆类型
多克隆
标记
非结合性
应用范围
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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抗原表位
- AA 10-90, Cleaved-Ile20
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原理
- Cleaved-Factor XII HC (I20) Polyclonal Antibody
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特异性
- Cleaved-Factor XII HC (I20) Polyclonal Antibody detects endogenous levels of fragment of activated Factor XII HC protein resulting from cleavage adjacent to I20.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from the N-terminal region of human Factor XII HC at AA range: 10-90
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亚型
- IgG
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anti-Factor 12 Heavy Chain (F12) antibody
F12 适用: 人, 小鼠, 大鼠 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Factor 12 Heavy Chain (F12) (Arg372), (cleaved) antibodyF12 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- Factor 12 Heavy Chain (F12)
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别名
- Factor XII HC
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背景
- Rabbit Anti-Cleaved-Factor XII HC (I20) Polyclonal Antibody,F12, Coagulation factor XII, Hageman factor, HAF,F12 encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.,Coagulation factor XII
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基因ID
- 2161
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UniProt
- P00748
抗原
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