EPOR 抗体 (pTyr426)
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北京 101111
Quick Overview for EPOR 抗体 (pTyr426) (ABIN7213362)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr426
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原理
- EpoR (phospho Tyr426) Polyclonal Antibody
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特异性
- Phospho-EpoR (Y426) Polyclonal Antibody detects endogenous levels of EpoR protein only when phosphorylated at Y426.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from human EpoR Phospho-Tyr426
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:20000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- EPOR (Erythropoietin Receptor (EPOR))
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别名
- EpoR
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背景
- Rabbit Anti-EpoR (phospho Tyr426) Polyclonal Antibody,EPOR, Erythropoietin receptor, EPO-R,EPOR encodes the erythropoietin receptor (erythropoietin receptor) which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of EPOR may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.,Erythropoietin receptor
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分子量
- observerd band 55kDa
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基因ID
- 2057
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UniProt
- P19235
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途径
- JAK/STAT Signaling
抗原
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