ELL3 抗体 (AA 210-290)
This 兔 多克隆 anti-ELL3 antibody specifically detects ELL3 in WB 和 ELISA. The antibody is reactive with 人 和 小鼠 samples.
产品编号 ABIN7228382
发货至:
中国
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中国
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北京 101111
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Quick Overview for ELL3 抗体 (AA 210-290) (ABIN7228382)
抗原
See all ELL3 抗体
ELL3
(Elongation Factor RNA Polymerase II-Like 3 (ELL3))
适用
人, 小鼠
宿主
兔
克隆类型
多克隆
标记
This ELL3 antibody is un-conjugated
应用范围
Western Blotting (WB), ELISA
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抗原表位
- AA 210-290
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原理
- ELL3 Polyclonal Antibody
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特异性
- The antibody detects endogenous levels of ELL3 protein
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen
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免疫原
- Synthesized peptide derived from part region of human ELL3 protein at AA range: 210-290
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亚型
- IgG
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anti-Elongation Factor RNA Polymerase II-Like 3 (ELL3) (AA 1-397) antibody
ELL3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- ELL3 (Elongation Factor RNA Polymerase II-Like 3 (ELL3))
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别名
- ELL3
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背景
- Rabbit Anti-ELL3 Polyclonal Antibody,RNA polymerase II elongation factor ELL3,ELL3 (Elongation Factor For RNA Polymerase II 3) is a Protein Coding gene. Among its related pathways are RNA polymerase II transcribes snRNA genes and Gene Expression. Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity). Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.,ELL3
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分子量
- observerd band 43kDa
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基因ID
- 80237
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UniProt
- Q9HB65
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途径
- Negative Regulation of intrinsic apoptotic Signaling
抗原
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