DNA Polymerase zeta (AA 200-280) 抗体
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Quick Overview for DNA Polymerase zeta (AA 200-280) 抗体 (ABIN7224004)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 200-280
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原理
- DNA pol ζ Polyclonal Antibody
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特异性
- DNA pol ζ Polyclonal Antibody detects endogenous levels of DNA pol ζ protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from the N-terminal region of human DNA pol zeta at AA range: 200-280
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- DNA Polymerase zeta
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别名
- DNA pol zeta
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背景
- Rabbit Anti-DNA pol ζ Polyclonal Antibody,REV3L, POLZ, REV3, DNA polymerase zeta catalytic subunit, Protein reversionless 3-like, REV3-like, hREV3,DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches. These exonucleases include the family of DNA polymerases. DNA pol α, β, δ, and e are involved in DNA replication and repair. DNA pol δ and DNA pol e are multisubunit enzymes, with DNA pol δ consisting of two subunits p125, which interacts with the sliding DNA clamp protein PCNA, and p50. The nuclear-encoded DNA pol γ is the only DNA polymerase required for the replication of the mitochondrial DNA. DNA pol Ω is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage-induced mutagenesis. DNA pol is a DNA polymerase-helicase that binds ATP and is involved in the repair of interstrand crosslinks.,DNA polymerase zeta catalytic subunit
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基因ID
- 5980
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UniProt
- O60673
抗原
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