CRYAB 抗体 (pSer59)
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Quick Overview for CRYAB 抗体 (pSer59) (ABIN7219704)
抗原
See all CRYAB 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer59
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原理
- Rabbit Anti-Crystallin-αB (phospho Ser59) Polyclonal Antibody
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特异性
- Phospho-Crystallin-αB (S59) Polyclonal Antibody detects endogenous levels of Crystallin-αB protein only when phosphorylated at S59.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthesized peptide derived from human Crystallin-alphaB Phospho-Ser59
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亚型
- IgG
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anti-Crystallin, alpha B (CRYAB) (AA 1-175) antibody
CRYAB 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Crystallin, alpha B (CRYAB) antibodyCRYAB 适用: 人 WB, IHC, IHC (p), IP, FACS 宿主: 小鼠 Monoclonal 6G5 unconjugated
anti-Crystallin, alpha B (CRYAB) antibodyCRYAB 适用: 人, 大鼠 WB, IHC 宿主: 小鼠 Monoclonal CPTC-CRYAB-1 unconjugated
anti-Crystallin, alpha B (CRYAB) (AA 30-151) antibodyCRYAB 适用: 人, 大鼠, 小鼠, 猴 WB, IHC, ELISA, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Crystallin, alpha B (CRYAB) antibody (Atto 488)CRYAB 适用: 人 WB, IHC, ELISA, IF, ICC 宿主: 小鼠 Monoclonal 3A10-C9 Atto 488
anti-Crystallin, alpha B (CRYAB) antibody (Atto 594)CRYAB 适用: 人 WB, IHC, ELISA, IF, ICC 宿主: 小鼠 Monoclonal 3A10-C9 Atto 594
anti-Crystallin, alpha B (CRYAB) antibody (PE)CRYAB 适用: 人 WB, IHC, ELISA, IF, ICC 宿主: 小鼠 Monoclonal 3A10-C9 PE
anti-Crystallin, alpha B (CRYAB) antibody (PerCP)CRYAB 适用: 人 WB, IHC, ELISA, IF, ICC 宿主: 小鼠 Monoclonal 3A10-C9 PerCP
anti-Crystallin, alpha B (CRYAB) antibody (Biotin)CRYAB 适用: 人 WB, IHC, ELISA, IF, ICC 宿主: 小鼠 Monoclonal 3A10-C9 Biotin
anti-Crystallin, alpha B (CRYAB) antibody (FITC)CRYAB 适用: 人 WB, IHC, ELISA, IF, ICC 宿主: 小鼠 Monoclonal 3A10-C9 FITC
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,ELISA 1:5000,IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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有效期
- 12 months
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- CRYAB (Crystallin, alpha B (CRYAB))
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别名
- Crystallin-alphaB
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背景
- CRYAB, CRYA2, Alpha-crystallin B chain, Alpha(B)-crystallin, Heat shock protein beta-5, HspB5, Renal carcinoma antigen NY-REN-27, Rosenthal fiber componentMammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone, instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits, the alpha-A and alpha-B subunits have a 3: 1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The crystallin alpha B has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed, alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases, a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants.
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基因ID
- 1410
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UniProt
- P02511
抗原
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