CENPJ 抗体 (AA 510-590)
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北京 101111
Quick Overview for CENPJ 抗体 (AA 510-590) (ABIN7227832)
抗原
See all CENPJ 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 510-590
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原理
- Rabbit Anti-CENPJ Polyclonal Antibody
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特异性
- The antibody detects endogenous levels of CENPJ protein
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthesized peptide derived from part region of human CENPJ protein at AA range: 510-590
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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有效期
- 12 months
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- CENPJ (Centromere Protein J (CENPJ))
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别名
- CENPJ
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背景
- Centromere protein J, CENP-J, Centrosomal P4.1-associated protein, LAG-3-associated protein, LYST-interacting protein 1CENPJ (Centromere Protein J) encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in CENPJ are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and cognitive disability. Alternatively spliced transcript variants have been found for CENPJ.
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分子量
- 147kD
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基因ID
- 55835
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UniProt
- Q9HC77
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途径
- M Phase
抗原
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