CCAR2 抗体 (AA 400-480)
Quick Overview for CCAR2 抗体 (AA 400-480) (ABIN7223830)
抗原
See all CCAR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 400-480
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原理
- DBC-1 Polyclonal Antibody
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特异性
- DBC-1 Polyclonal Antibody detects endogenous levels of DBC-1 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from the Internal region of human DBC-1 at AA range: 400-480
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亚型
- IgG
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anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 654-923) antibody
CCAR2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 1-923) antibodyCCAR2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 1-923) antibodyCCAR2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 5-365) antibodyCCAR2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4E6 unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) antibodyCCAR2 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 25GB70 unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) antibodyCCAR2 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (Internal Region) antibodyCCAR2 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) antibodyCCAR2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 842-855) antibodyVerified CCAR2 适用: 人, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:20000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))
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别名
- DBC-1
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背景
- Rabbit Anti-DBC-1 Polyclonal Antibody,KIAA1967, DBC1, DBIRD complex subunit KIAA1967, Deleted in breast cancer gene 1 protein, DBC-1, DBC.1, p30 DBC,Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed: 18235501, PubMed: 18235502, PubMed: 19131338, PubMed: 19218236, PubMed: 22446626, PubMed: 23352644, PubMed : 23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed: 20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed: 24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed: 21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed: 24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed: 25661920). Plays an important role in tumor suppression through p53/TP53 regulation, stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed: 25732823). Represses the transcriptional activator activity of BRCA1 (PubMed: 20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed: 25361978).,DBIRD complex subunit KIAA1967
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分子量
- observerd band 102kDa
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基因ID
- 57805
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UniProt
- Q8N163
抗原
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