Caspase-8 p18 抗体 (Cleaved-Ser217)
This 兔 多克隆 anti-Caspase-8 p18 antibody specifically detects Caspase-8 p18 in WB 和 ELISA. The antibody is reactive with 人 samples.
产品编号 ABIN7226638
发货至:
中国
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Our Local Distributor
中国
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北京 101111
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Quick Overview for Caspase-8 p18 抗体 (Cleaved-Ser217) (ABIN7226638)
抗原
Caspase-8 p18
(Caspase 8 Subunit P18)
适用
人
宿主
兔
克隆类型
多克隆
标记
This Caspase-8 p18 antibody is un-conjugated
应用范围
Western Blotting (WB), ELISA
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抗原表位
- AA 170-250, Cleaved-Ser217
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原理
- Cleaved-Caspase-8 p18 (S217) Polyclonal Antibody
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特异性
- Cleaved-Caspase-8 p18 (S217) Polyclonal Antibody detects endogenous levels of Cleaved-Caspase-8 p18 (S217) protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from the Internal region of human Cleaved-Caspase-8 p18 (S217) at AA range: 170-250
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亚型
- IgG
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anti-Caspase 8 Subunit P18 (cleaved), (Ser217) antibody
适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- Caspase-8 p18 (Caspase 8 Subunit P18)
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别名
- Caspase-8 p18
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背景
- Rabbit Anti-Cleaved-Caspase-8 p18 (S217) Polyclonal Antibody,CASP8, MCH5, Caspase-8, CASP-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog, MACH,CASP8 (caspase 8) encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.,Caspase-8
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分子量
- observerd band 54kDa
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基因ID
- 841
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UniProt
- Q14790
抗原
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