RORB 抗体 (AA 385-470) (Biotin)
Quick Overview for RORB 抗体 (AA 385-470) (Biotin) (ABIN715873)
抗原
See all RORB 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 385-470
-
交叉反应
- 小鼠, 大鼠
-
预测反应
- Human,Dog,Cow,Sheep,Horse
-
纯化方法
- Purified by Protein A.
-
免疫原
- KLH conjugated synthetic peptide derived from human RORB
-
亚型
- IgG
-
-
-
-
应用备注
-
WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C for 12 months.
-
有效期
- 12 months
-
-
- RORB (RAR-Related Orphan Receptor B (RORB))
-
别名
- ROR beta
-
背景
-
Synonyms: NR1F2, Nuclear receptor ROR-beta, Nuclear receptor RZR beta, Nuclear receptor RZR-beta, Nuclear receptor subfamily 1 group F member 2, RAR related orphan receptor B, RAR related orphan receptor beta, Retinoic acid binding receptor beta, Retinoid-related orphan receptor-beta, ROR BETA, Rorb, RORB_HUMAN, RZR BETA, RZRB.
Background: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity)
-
基因ID
- 6096
-
UniProt
- Q92753
-
途径
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway
抗原
-