CA8 抗体 (Internal Region)
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Quick Overview for CA8 抗体 (Internal Region) (ABIN7225002)
抗原
See all CA8 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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原理
- CA VIII Polyclonal Antibody
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特异性
- CA VIII Polyclonal Antibody detects endogenous levels of CA VIII protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from the Internal region of human CA VIII
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), ELISA (1:40000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- CA8 (Carbonic Anhydrase VIII (CA8))
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别名
- CA VIII
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背景
- Rabbit Anti-CA VIII Polyclonal Antibody,CA8, CALS, Carbonic anhydrase-related protein, CARP, Carbonic anhydrase VIII, CA-VIII,The protein encoded by CA8 (carbonic anhydrase 8) was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e. The reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in CA8 are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in CA8 are associated with osteoporosis, and overexpression of CA8 in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants.,Carbonic anhydrase-related protein
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基因ID
- 767
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UniProt
- P35219
抗原
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