CAPN10 抗体 (N-Term)
Quick Overview for CAPN10 抗体 (N-Term) (ABIN7219246)
抗原
See all CAPN10 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- Calpain 10 Polyclonal Antibody
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特异性
- Calpain 10 Polyclonal Antibody detects endogenous levels of Calpain 10 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from the N-terminal region of human Calpain 10
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- CAPN10 (Calpain 10 (CAPN10))
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别名
- Calpain 10
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背景
- Rabbit Anti-Calpain 10 Polyclonal Antibody,CAPN10, KIAA1845, Calpain-10, Calcium-activated neutral proteinase 10, CANP 10,Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation, domain II, the protease domain, domain III, a linker domain of unknown function, and domain IV, the calmodulin-like calcium-binding domain. CAPN10 encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. CAPN10 is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene.,Calpain-10
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分子量
- observerd band 75kDa
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基因ID
- 11132
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UniProt
- Q9HC96
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途径
- Positive Regulation of Peptide Hormone Secretion
抗原
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