BCAS2 抗体 (AA 150-230)
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北京 101111
Quick Overview for BCAS2 抗体 (AA 150-230) (ABIN7213778)
抗原
See all BCAS2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 150-230
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原理
- BCAS2 Polyclonal Antibody
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特异性
- BCAS2 Polyclonal Antibody detects endogenous levels of BCAS2 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from the C-terminal region of human BCAS2 at AA range: 150-230
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亚型
- IgG
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anti-Breast Carcinoma Amplified Sequence 2 (BCAS2) (AA 116-225) antibody
BCAS2 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 1D10 unconjugated
anti-Breast Carcinoma Amplified Sequence 2 (BCAS2) (AA 1-225) antibodyBCAS2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Breast Carcinoma Amplified Sequence 2 (BCAS2) (AA 151-225) antibodyBCAS2 适用: 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Breast Carcinoma Amplified Sequence 2 (BCAS2) (AA 1-225) antibodyBCAS2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Breast Carcinoma Amplified Sequence 2 (BCAS2) (AA 116-225) antibodyBCAS2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Breast Carcinoma Amplified Sequence 2 (BCAS2) (Internal Region) antibodyBCAS2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Breast Carcinoma Amplified Sequence 2 (BCAS2) (C-Term) antibodyBCAS2 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Breast Carcinoma Amplified Sequence 2 (BCAS2) (N-Term) antibodyBCAS2 适用: 人, 小鼠, 大鼠, 猴, Cow, 犬, 兔, 豚鼠, 马, 斑马鱼, 小鸡, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Breast Carcinoma Amplified Sequence 2 (BCAS2) (C-Term) antibodyBCAS2 适用: 人, 小鼠, 大鼠, 猴, Cow, 犬, 兔, 小鸡, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Breast Carcinoma Amplified Sequence 2 (BCAS2) (N-Term) antibodyBCAS2 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- BCAS2 (Breast Carcinoma Amplified Sequence 2 (BCAS2))
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别名
- BCAS2
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背景
- Rabbit Anti-BCAS2 Polyclonal Antibody,BCAS2, DAM1, Pre-mRNA-splicing factor SPF27, Breast carcinoma-amplified sequence 2, DNA amplified in mammary carcinoma 1 protein, Spliceosome-associated protein SPF 27,BCAS2 was identified through differential display analysis as an mRNA species that was overexpressed in MCF7 and BT-20 breast cancer cell lines. The chromosomal region containing this gene, 1p13.3021, is amplified in these cells lines. BCAS2 is a transcriptional cofactor that enhances estrogen receptor-mediated gene expression, and directly interacts with the tumor suppressor p53 to reduce p53 transcriptional activity by reducing p53 protein level in the absence of DNA damage. Deprivation of BCAS2 through RNA inhibition induces apoptosis in p53-wild type cells, but causes G2-M arrest in p53- or -mutant cells, this effect was reversed with the expression of ectopic BCAS2. BCAS2 may thus be potentially useful as a therapeutic target in the treatment of cancer.,Pre-mRNA-splicing factor SPF27
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基因ID
- 10286
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UniProt
- O75934
抗原
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