AMH 抗体 (AA 380-460)
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Quick Overview for AMH 抗体 (AA 380-460) (ABIN7229680)
抗原
See all AMH 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 380-460
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原理
- MIS Polyclonal Antibody
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特异性
- The antibody detects endogenous levels of MIS protein
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen
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免疫原
- Synthesized peptide derived from part region of human MIS protein at AA range: 380-460
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- AMH (Anti-Mullerian Hormone (AMH))
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别名
- MIS
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背景
- Rabbit Anti-MIS Polyclonal Antibody,Anti-Muellerian hormone, AMH, Muellerian-inhibiting substance, MIS,AMH encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome.,MIS
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分子量
- observerd band 61kDa
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基因ID
- 268
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UniProt
- P03971
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途径
- Negative Regulation of Hormone Secretion
抗原
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