Recombinant PDCD1 (Pembrolizumab Biosimilar) 抗体
This anti-PDCD1 (Pembrolizumab Biosimilar) antibody is a 小鼠 单克隆 antibody detecting PDCD1 (Pembrolizumab Biosimilar) in FACS 和 in vivo. Suitable for 人.
Quick Overview for Recombinant PDCD1 (Pembrolizumab Biosimilar) 抗体 (ABIN7200668)
抗原
PDCD1 (Pembrolizumab Biosimilar)
抗体类型
Recombinant Antibody
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This PDCD1 (Pembrolizumab Biosimilar) antibody is un-conjugated
应用范围
Flow Cytometry (FACS), In vivo Studies (in vivo)
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原理
- Pembrolizumab Biosimilar, Human PD-1 Monoclonal Antibody
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特异性
- The in vivo grade pembrolizumab biosimilar specifically binds to the programmed cell death protein 1 (PD-1 or PD1), antagonizing its interaction with its known ligands PD-L1 or PDL1, and PD-L2 or PDL2.
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产品特性
- Recombinant Humanized IgG4 Monoclonal Antibody.
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纯化方法
- Protein A affinity column
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纯度
- > 95% by SDS-PAGE under reducing conditions and HPLC.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1 EU per 1 mg of the protein by the LAL method.
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免疫原
- The anti-human programmed cell death protein 1 (PD-1) monoclonal antibody pembrolizumab biosimilar was produced in the pembrolizumab biosimilar CHO stable cell line.
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亚型
- IgG4 kappa
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anti-PDCD1 (Pembrolizumab Biosimilar) antibody
Research Grade 适用: 人 FACS, ELISA 宿主: Humanized Monoclonal unconjugated Recombinant Antibody
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应用备注
- ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by pembrolizumab.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, pH 7.4, no stabilizers or preservatives.
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储存液
- Without preservative
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注意事项
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
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有效期
- 12 months
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- PDCD1 (Pembrolizumab Biosimilar)
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物质类
- Biosimilar
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背景
- What is Pembrolizumab biosimilar research grade? Pembrolizumab is a highly selective IgG4-kappa humanized monoclonal antibody against PD-1 receptor. It was generated by grafting the variable sequences of a very high-affinity mouse antihuman PD-1 antibody onto a human IgG4-kappa isotype with the containing a stabilizing S228P Fc mutation. It contains 32 cysteine residues and the complete folded molecule includes 4 disulfide linkages as interchain bonds and 23 interchain bonds. Pembrolizumab Biosimilar uses the same protein sequences as the therapeutic antibody pembrolizumab.
抗原
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