Recombinant PDCD1 (Pembrolizumab Biosimilar) 抗体
This anti-PDCD1 (Pembrolizumab Biosimilar) antibody (ABIN7200668) is a Mouse Monoclonal antibody detecting PDCD1 (Pembrolizumab Biosimilar) in FACS, in vivo. Suitable for Human.
Quick Overview for Recombinant PDCD1 (Pembrolizumab Biosimilar) 抗体 (ABIN7200668)
抗原
PDCD1 (Pembrolizumab Biosimilar)
抗体类型
Recombinant Antibody
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This PDCD1 (Pembrolizumab Biosimilar) antibody is un-conjugated
应用范围
Flow Cytometry (FACS), In vivo Studies (in vivo)
-
-
原理
- Pembrolizumab Biosimilar, Human PD-1 Monoclonal Antibody
-
特异性
- The in vivo grade pembrolizumab biosimilar specifically binds to the programmed cell death protein 1 (PD-1 or PD1), antagonizing its interaction with its known ligands PD-L1 or PDL1, and PD-L2 or PDL2.
-
产品特性
- Recombinant Humanized IgG4 Monoclonal Antibody.
-
纯化方法
- Protein A affinity column
-
纯度
- > 95% by SDS-PAGE under reducing conditions and HPLC.
-
过滤
- 0.2 μm filtered
-
内毒素水平
- < 1 EU per 1 mg of the protein by the LAL method.
-
免疫原
- The anti-human programmed cell death protein 1 (PD-1) monoclonal antibody pembrolizumab biosimilar was produced in the pembrolizumab biosimilar CHO stable cell line.
-
亚型
- IgG4 kappa
-
-
anti-PDCD1 (Pembrolizumab Biosimilar) antibody
Research Grade 适用: 人 FACS, ELISA 宿主: Humanized Monoclonal unconjugated Recombinant Antibody
-
-
应用备注
- ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by pembrolizumab.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- PBS, pH 7.4, no stabilizers or preservatives.
-
储存液
- Without preservative
-
注意事项
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
-
有效期
- 12 months
-
-
- PDCD1 (Pembrolizumab Biosimilar)
-
物质类
- Biosimilar
-
背景
- What is Pembrolizumab biosimilar research grade? Pembrolizumab is a highly selective IgG4-kappa humanized monoclonal antibody against PD-1 receptor. It was generated by grafting the variable sequences of a very high-affinity mouse antihuman PD-1 antibody onto a human IgG4-kappa isotype with the containing a stabilizing S228P Fc mutation. It contains 32 cysteine residues and the complete folded molecule includes 4 disulfide linkages as interchain bonds and 23 interchain bonds. Pembrolizumab Biosimilar uses the same protein sequences as the therapeutic antibody pembrolizumab.
抗原
-
You are here:
