Recombinant TNF alpha (Infliximab Biosimilar) 抗体
This anti-TNF alpha (Infliximab Biosimilar) antibody is a 小鼠 单克隆 antibody detecting TNF alpha (Infliximab Biosimilar) in FACS 和 in vivo. Suitable for 人.
Quick Overview for Recombinant TNF alpha (Infliximab Biosimilar) 抗体 (ABIN7200661)
抗原
TNF alpha (Infliximab Biosimilar)
抗体类型
Recombinant Antibody
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This TNF alpha (Infliximab Biosimilar) antibody is un-conjugated
应用范围
Flow Cytometry (FACS), In vivo Studies (in vivo)
克隆位点
CA2
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原理
- Infliximab Biosimilar, TNF alpha Monoclonal Antibody
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特异性
- The monoclonal antibody Infliximab biosimilar specifically binds to the human TNF alpha.
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产品特性
- Recombinant Chimeric IgG1 Monoclonal Antibody.
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纯化方法
- Protein A affinity column
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纯度
- > 95% by SDS-PAGE under reducing conditions and HPLC.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1 EU per 1 mg of the protein by the LAL method.
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免疫原
- The monoclonal antibody Infliximab biosimilar was produced in the Infliximab biosimilar CHO stable cell line.
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亚型
- IgG1 kappa
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anti-TNF alpha (Infliximab Biosimilar) antibody
适用: 人 FACS, in vivo, ELISA 宿主: Human Chimeric cA2 unconjugated Recombinant Antibody
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应用备注
- ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by Infliximab.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, pH 7.4, no stabilizers or preservatives.
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储存液
- Without preservative
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注意事项
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
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有效期
- 12 months
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- TNF alpha (Infliximab Biosimilar)
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物质类
- Biosimilar
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背景
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Infliximab, a chimeric anti-TNF-α monoclonal antibody, is used to treat psoriasis, Crohn's disease, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, and ulcerative colitis. Infliximab interferes TNF-α from binding to its receptor in the cell.
Mainly produced by activated macrophages (M1), Tumor necrosis factor (TNF, cachexin, cachectin, tumor necrosis factor alpha, TNFα) plays important roles in the regulation of autoimmune reaction.
抗原
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