Recombinant MS4A1 (Rituximab Biosimilar) 抗体
This anti-MS4A1 (Rituximab Biosimilar) antibody is a 小鼠 单克隆 antibody detecting MS4A1 (Rituximab Biosimilar) in FACS 和 in vivo. Suitable for 人.
Quick Overview for Recombinant MS4A1 (Rituximab Biosimilar) 抗体 (ABIN7200660)
抗原
MS4A1 (Rituximab Biosimilar)
抗体类型
Recombinant Antibody
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This MS4A1 (Rituximab Biosimilar) antibody is un-conjugated
应用范围
Flow Cytometry (FACS), In vivo Studies (in vivo)
克隆位点
10F381
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原理
- Rituximab Biosimilar, CD20 Monoclonal Antibody
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特异性
- The monoclonal antibody rituximab biosimilar specifically binds to the human TNF alpha.
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产品特性
- Recombinant Humanized IgG1 Monoclonal Antibody.
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纯化方法
- Protein A affinity column
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纯度
- > 95% by SDS-PAGE under reducing conditions and HPLC.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1 EU per 1 mg of the protein by the LAL method.
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免疫原
- The monoclonal antibody rituximab biosimilar was produced in the Rituximab biosimilar CHO stable cell line.
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亚型
- IgG1 kappa
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anti-MS4A1 (Rituximab Biosimilar) antibody
适用: 人, Cynomolgus, 猕猴 FACS 宿主: 兔 Chimeric 10F381 unconjugated Recombinant Antibody
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应用备注
- ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by rituximab.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, pH 7.4, no stabilizers or preservatives.
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储存液
- Without preservative
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注意事项
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
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有效期
- 12 months
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- MS4A1 (Rituximab Biosimilar)
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物质类
- Biosimilar
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背景
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B-lymphocyte antigen CD20 encoded by the MS4A1 gene is an activated-glycosylated phosphoprotein on the surface of all B-cells. The function of the membrane protein is to stimulate B-cell immune response, specifically against T-independent antigens though its natural ligand remains unknown. CD20 is important for the development and differentiation of B-cells into plasma cells. CD20 belongs to the membrane-spanning 4A family with common structural features, similar intron/exon splice boundaries, and unique expression patterns among hematopoietic cells and nonlymphoid tissues.
Rituximab, a chimeric anti-CD20 monoclonal antibody, destroys B cells and is used to treat diseases with excessive numbers of B cells, overactive B cells, or dysfunctional B cells, such as many lymphomas, leukemias, transplant rejection, and autoimmune disorders.
抗原
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