Recombinant ErbB2/Her2 (Pertuzumab Biosimilar) 抗体
This anti-ErbB2/Her2 (Pertuzumab Biosimilar) antibody is a 小鼠 单克隆 antibody detecting ErbB2/Her2 (Pertuzumab Biosimilar) in FACS 和 in vivo. Suitable for 人.
Quick Overview for Recombinant ErbB2/Her2 (Pertuzumab Biosimilar) 抗体 (ABIN7200658)
抗原
ErbB2/Her2 (Pertuzumab Biosimilar)
抗体类型
Recombinant Antibody
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This ErbB2/Her2 (Pertuzumab Biosimilar) antibody is un-conjugated
应用范围
Flow Cytometry (FACS), In vivo Studies (in vivo)
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原理
- Pertuzumab Biosimilar, Human HER2 Monoclonal Antibody
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特异性
- The monoclonal antibody pertuzumab biosimilar specifically binds to the human HER2/ErbB-2/c-neu.
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产品特性
- Recombinant humanized IgG1 Monoclonal Antibody.
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纯化方法
- Protein A affinity column
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纯度
- > 95% by SDS-PAGE under reducing conditions and HPLC.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1 EU per 1 mg of the protein by the LAL method.
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免疫原
- The monoclonal antibody pertuzumab biosimilar was produced in the pertuzumab biosimilar CHO stable cell line.
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亚型
- IgG1 kappa
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应用备注
- ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by pertuzumab.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, pH 7.4, no stabilizers or preservatives.
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储存液
- Without preservative
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注意事项
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
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有效期
- 12 months
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- ErbB2/Her2 (Pertuzumab Biosimilar)
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物质类
- Biosimilar
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背景
- Pertuzumab, a humanized monoclonal antibody, inhibits HER dimerization and is used for the treatment of HER2-positive metastatic breast cancer, in combination with trastuzumab and docetaxel. By binding to HER2, Pertuzumab inhibits the dimerization of HER2 with other HER receptors, resulting in slowed tumor growth.
抗原
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