USP28 抗体 (AA 101-200) (HRP)
Quick Overview for USP28 抗体 (AA 101-200) (HRP) (ABIN715250)
抗原
See all USP28 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 101-200
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交叉反应
- 小鼠
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预测反应
- Human,Rat
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human USP28
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亚型
- IgG
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anti-Ubiquitin Specific Peptidase 28 (USP28) (AA 430-580) antibody
USP28 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 28 (USP28) (AA 430-580) antibodyUSP28 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 28 (USP28) (AA 1-583) antibodyUSP28 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 28 (USP28) (N-Term) antibodyUSP28 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 28 (USP28) (Internal Region) antibodyVerified USP28 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 28 (USP28) (C-Term) antibodyUSP28 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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注意事项
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- USP28 (Ubiquitin Specific Peptidase 28 (USP28))
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别名
- USP28
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背景
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Synonyms: Deubiquitinating enzyme 28, KIAA1515, Ubiquitin carboxyl terminal hydrolase 28, Ubiquitin carboxyl-terminal hydrolase 28, Ubiquitin specic peptidase 28, Ubiquitin specic processing protease 28, Ubiquitin specic protease 28, Ubiquitin thioesterase 28, Ubiquitin thiolesterase 28, Ubiquitin-specic-processing protease 28, UBP28_HUMAN, USP 28, USP28, USP28 protein, USP-28.
Background: Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus.
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基因ID
- 57646
抗原
-
