PRPS1 抗体
Quick Overview for PRPS1 抗体 (ABIN7192028)
抗原
See all PRPS1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- PRPS1/PRPS2/PRPS1L1 Antibody
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交叉反应
- 小鼠
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纯化方法
- Antigen affinity purification
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免疫原
- Synthetic peptide of Human PRPS1/2/1L1
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亚型
- IgG
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anti-phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) (N-Term) antibody
PRPS1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) (AA 1-318) antibodyPRPS1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) antibodyPRPS1 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) (AA 1-100) antibodyPRPS1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) (N-Term) antibodyPRPS1 适用: 人, 小鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- PRPS1 (phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1))
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别名
- PRPS1
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背景
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Background: PRPS (phosphoribosyl pyrophosphate synthetase) proteins catalyze the synthesis of phosphoribosyl pyrophosphate (PRPP). Three human PRPS isoforms exist and are encoded by three different genes. PRPS1 and PRPS2 (also known as PRS1 and PRS2, respectively) are ubiquitously expressed, while PRPS3 (also known as PRPS1L1) is specific to the testis. PRPP is an important substrate synthesized from MgATP and ribose-5-phosphate in a reaction that requires inorganic phosphate and magnesium as a cofactor. PRPP is essential in the synthesis of nearly all nucleotides, implying that PRPS1/2 play an important role in nucleotide biosynthesis and purine metabolism. A mutation in the gene encoding PRPS1 may result in PRPS superactivity, a disease characterized by gout and the overproduction of purine nucleotides, uric acid and PRPP. PRPS1 mutations can also lead to a reduction in PRPS1 activity resulting in ARTS syndrome or CMTX5 (Charcot-Marie-Tooth disease X-linked recessive type 5).
Aliases: phosphoribosyl pyrophosphate synthetase 1/2/1-like 1
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UniProt
- P60891, P11908, P21108
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途径
- Ribonucleoside Biosynthetic Process
抗原
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