CHRDL2 抗体
Quick Overview for CHRDL2 抗体 (ABIN7190246)
抗原
See all CHRDL2 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人
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纯化方法
- Antigen affinity purification
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免疫原
- Synthetic peptide of Human CHRDL2
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亚型
- IgG
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anti-Chordin-Like 2 (CHRDL2) (AA 1-451) antibody
CHRDL2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chordin-Like 2 (CHRDL2) (AA 1-451) antibodyCHRDL2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Chordin-Like 2 (CHRDL2) (AA 26-169) antibodyCHRDL2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- CHRDL2 (Chordin-Like 2 (CHRDL2))
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别名
- CHRDL2
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背景
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Background: CHRDL2 (chordin-related protein 2), also known as BNF1 (breast tumor novel factor 1) or CHL2 (chordin-like 2), is a 429 amino acid protein that belongs to the chordin family of proteins. CHRDL2 contains three VWFC (von Willebrand Factor type C) domains and is predominantly expressed in uterus and moderately expressed in prostate, liver, ovary, heart and testis. Due to alternative splicing events, CHRDL2 exists as five isoforms, namely isoform I, isoform II, isoform VII, isoform VIII and isoform IX. Two of these isoforms are secreted, while the other three localize to the cytoplasm. Functioning as a BMP-binding inhibitor, CHRDL2 directly interacts with BMPs and blocks their binding to BMP receptors, thereby inhibiting BMP activity. In breast, lung and colon tumors, CHRDL2 expression is upregulated, suggesting a possible role in tumorigenesis.
Aliases: BNF-1 antibody, BNF1 antibody, Breast tumor novel factor 1 antibody, CHL2 antibody, chordin like 2 antibody, Chordin like protein 2 precursor antibody, Chordin related protein 2 antibody, Chordin-like protein 2 antibody, Chordin-related protein 2 antibody, Chrdl2 antibody, CRDL2_HUMAN antibody, DKFZp586N2124 antibody, FKSG37 antibody
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UniProt
- Q6WN34
抗原
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