POLR3D 抗体
Quick Overview for POLR3D 抗体 (ABIN7184078)
抗原
See all POLR3D 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthesized peptide derived from internal of Human RPC4.
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亚型
- IgG
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anti-Polymerase (RNA) III (DNA Directed) Polypeptide D, 44kDa (POLR3D) (AA 1-398) antibody
POLR3D 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Polymerase (RNA) III (DNA Directed) Polypeptide D, 44kDa (POLR3D) (AA 296-395) antibodyPOLR3D 适用: 人 ELISA 宿主: 小鼠 Monoclonal 4E6 unconjugated
anti-Polymerase (RNA) III (DNA Directed) Polypeptide D, 44kDa (POLR3D) (Internal Region) antibodyPOLR3D 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB:1:500-1:3000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- POLR3D (Polymerase (RNA) III (DNA Directed) Polypeptide D, 44kDa (POLR3D))
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别名
- POLR3D
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背景
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Background: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway By similarity.
Ittmann M., Mol. Cell. Biol. 7:3386-3393(1987).
Hu P., Mol. Cell. Biol. 22:8044-8055(2002).
Kalnine N., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.Aliases: POLR3D antibody, BN51 antibody, BN51T antibody, DNA-directed RNA polymerase III subunit RPC4 antibody, RNA polymerase III subunit C4 antibody, DNA-directed RNA polymerase III subunit D antibody, Protein BN51 antibody, RNA polymerase III 47 kDa subunit antibody, RPC53 homolog antibody
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UniProt
- P05423
抗原
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