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NEK2 抗体 (AA 1-100)

Name: NEK2 抗体 (AA 1-100)
SKU: ABIN713921
Availability: OutOfStock

This anti-NEK2 antibody is a 兔多克隆 antibody detecting NEK2 in WB, ELISA, IHC (p), IF (p), IF (cc) 和 IHC (fro). Suitable for 人. This Primary Antibody has been cited in 3+ publications.

(3 references)

产品编号 ABIN713921

发货至: 中国

Quick Overview for NEK2 抗体 (AA 1-100) (ABIN713921)

抗原

See all NEK2 抗体

NEK2 (NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2))

适用

人

宿主

兔

克隆类型

多克隆

标记

This NEK2 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Discover our top product NEK2 Primary Antibody

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AA 1-100

交叉反应

人

预测反应

Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human NEK2

亚型

IgG
anti-NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) (AA 148-397) antibody
NEK2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) (AA 331-445) antibody
NEK2 适用: 人 WB, ELISA, IP, IHC (p) 宿主: 小鼠 Monoclonal 2F6 unconjugated

anti-NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) (AA 331-445) antibody
NEK2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2F9 unconjugated

anti-NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) (AA 1-445) antibody
NEK2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) (AA 1-445) antibody
NEK2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated

anti-NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) (AA 282-295) antibody
NEK2 适用: 人 WB 宿主: 绵羊 Monoclonal unconjugated

anti-NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) (AA 331-445) antibody
NEK2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C8 unconjugated

anti-NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) (C-Term) antibody
NEK2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) (AA 125-393) antibody
NEK2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) (AA 396-426) antibody
NEK2 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Zeng, Han, Wang, Cai, Huang, Luo, Liu, Zhuo, Dai, Zhao, Liang, Zhong: "Overexpression of NIMA-related kinase 2 is associated with progression and poor prognosis of prostate cancer." in: BMC urology, Vol. 15, pp. 90, (2015) (PubMed).

Zhong, Guan, Dong, Yang, Liu, Zhang: "Examining Nek2 as a better proliferation marker in non-small cell lung cancer prognosis." in: Tumour biology, Vol. 35, Issue 7, pp. 7155-62, (2014) (PubMed).

Zhong, Guan, Liu, Zhang: "Aberrant expression of NEK2 and its clinical significance in non-small cell lung cancer." in: Oncology letters, Vol. 8, Issue 4, pp. 1470-1476, (2014) (PubMed).
抗原

NEK2 (NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2))

别名

NEK2

背景

Synonyms: NLK1, RP67, NEK2A, HsPK21, PPP1R111, Serine/threonine-protein kinase Nek2, HSPK 21, Never in mitosis A-related kinase 2, NimA-related protein kinase 2, NimA-like protein kinase 1, NEK2
Background: Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP25 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC8. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC2 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC, SGOL1, NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not.

基因ID

4751

UniProt

P51955

途径

M Phase