URI1 抗体 (C-Term)
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Quick Overview for URI1 抗体 (C-Term) (ABIN7180232)
抗原
See all URI1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- URI1 Antibody
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthesized peptide derived from C-terminal of Human RMP.
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亚型
- IgG
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anti-URI1, Prefoldin-Like Chaperone (URI1) (Middle Region) antibody
URI1 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-URI1, Prefoldin-Like Chaperone (URI1) (AA 180-298) antibodyURI1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-URI1, Prefoldin-Like Chaperone (URI1) antibodyURI1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-URI1, Prefoldin-Like Chaperone (URI1) (Internal Region) antibodyURI1 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-URI1, Prefoldin-Like Chaperone (URI1) (AA 371-475) antibodyURI1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-URI1, Prefoldin-Like Chaperone (URI1) (AA 1-495) antibodyURI1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-URI1, Prefoldin-Like Chaperone (URI1) (AA 359-408) antibodyURI1 适用: 人, 马, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-URI1, Prefoldin-Like Chaperone (URI1) (Middle Region) antibodyURI1 适用: 人, 小鼠, 大鼠, Cow, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- URI1 (URI1, Prefoldin-Like Chaperone (URI1))
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别名
- URI1
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背景
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Background: Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein. Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.
Van Leuven F., Genomics 54:511-520(1998).
Ota T., Nat. Genet. 36:40-45(2004).
Grimwood J., Nature 428:529-535(2004).
Aliases: C19orf2 antibody, Chromosome 19 open reading frame 2 antibody, NNX3 antibody, NNX3 protein antibody, PPP1R19 antibody, Protein NNX3 antibody, Protein phosphatase 1 regulatory subunit 19 antibody, RMP antibody, RMP_HUMAN antibody, RNA polymerase II subunit 5 mediating protein antibody, RNA polymerase II subunit 5-mediating protein antibody, RPB5 mediating protein antibody, RPB5-mediating protein antibody, Unconventional prefoldin RPB5 interactor 1 antibody, Unconventional prefoldin RPB5 interactor antibody, URI antibody, URI1 antibody, URI1, prefoldin-like chaperone antibody
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UniProt
- O94763
抗原
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