TAL1 抗体 (AA 1-324) (Biotin)
Quick Overview for TAL1 抗体 (AA 1-324) (Biotin) (ABIN7179879)
抗原
See all TAL1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-324
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交叉反应
- 斑马鱼
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Zebrafish T-cell acute lymphocytic leukemia protein 1 homolog protein (1-324AA)
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))
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别名
- tal1
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背景
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Background: Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells. Isoform alpha and isoform beta are redundant for the initiation of primitive hemopoiesis but have distinct roles in the regulation of primitive erythroid differentiation and definitive hemopoietic stem cell specification, most likely due to differences in expression levels. Specification of definitive hemopoietic stem cells requires isoform beta. DNA binding is required for erythroid maturation, but not for its other hemopoietic functions. Endothelial roles include development of the dorsal aorta, the site of definitive hemopoiesis in the embryo. Required for angiogenesis but not angioblast specification. Has an additional role in endocardium formation during heart development. May play a role in central nervous system development.
Aliases: tal1 antibody, scl antibody, tal-1 antibody, si:ch211-135j1.3 antibody, T-cell acute lymphocytic leukemia protein 1 homolog antibody, TAL-1 antibody, Stem cell protein antibody, zSCL antibody
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UniProt
- O93507
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途径
- Stem Cell Maintenance
抗原
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