Vpx Protein (VPX) (AA 1-112) 抗体 (HRP)
Quick Overview for Vpx Protein (VPX) (AA 1-112) 抗体 (HRP) (ABIN7179352)
抗原
See all Vpx Protein (VPX) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-112
-
交叉反应
- Simian Immunodeficiency Virus (SIV)
-
纯化方法
- >95%, Protein G purified
-
免疫原
- Recombinant Simian immunodeficiency virus Protein Vpx protein (1-112AA)
-
亚型
- IgG
-
-
anti-Vpx Protein (VPX) (AA 1-112), (subtype A) antibody
VPX 适用: Human Immunodeficiency Virus (HIV) ELISA, WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
-
- Vpx Protein (VPX)
-
别名
- vpx
-
物质类
- Viral Protein
-
背景
-
Background: Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.
Aliases: vpx antibody, Protein Vpx antibody, Viral protein X antibody, X ORF protein antibody
-
UniProt
- P11266
抗原
-
