WSS1 (AA 1-269) 抗体 (Biotin)
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北京 101111
Quick Overview for WSS1 (AA 1-269) 抗体 (Biotin) (ABIN7179221)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-269
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原理
- WSS1 Antibody, Biotin conjugated
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交叉反应
- Saccharomyces cerevisiae
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纯化方法
- Protein G purified
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纯度
- >95 %
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免疫原
- Recombinant Saccharomyces cerevisiae DNA-dependent metalloprotease WSS1 protein (1-269AA)
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- WSS1
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背景
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Background: Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped TOP1 from chromatin. DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways. May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites.
Aliases: WSS1 antibody, YHR134WDNA-dependent metalloprotease WSS1 antibody, EC 3.4.24.- antibody, DNA damage response protein WSS1 antibody, SUMO-dependent isopeptidase WSS1 antibody, Weak suppressor of SMT3 protein 1 antibody
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UniProt
- P38838
抗原
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