VP35 (AA 1-329) 抗体
The 兔 多克隆 anti-VP35 antibody is suitable to detect VP35 in samples from Reston Ebola virus. It has been validated for ELISA.
产品编号 ABIN7179135
发货至:
中国
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中国
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北京 101111
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Quick Overview for VP35 (AA 1-329) 抗体 (ABIN7179135)
抗原
VP35
适用
Reston Ebola virus
宿主
兔
克隆类型
多克隆
标记
非结合性
应用范围
ELISA
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抗原表位
- AA 1-329
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交叉反应
- Reston Ebola virus
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Reston ebolavirus Polymerase cofactor VP35 protein (1-329AA)
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- VP35
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背景
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Background: Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.
Aliases: VP35 antibody, Polymerase cofactor VP35 antibody
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UniProt
- Q91DE0
抗原
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