Cobra Venom Factor,CVF (AA 733-984) 抗体
Our Local Distributor
北京 101111
Quick Overview for Cobra Venom Factor,CVF (AA 733-984) 抗体 (ABIN7178124)
抗原
适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 733-984
-
原理
- Cobra venom factor Antibody
-
纯化方法
- Protein G purified
-
纯度
- >95 %
-
免疫原
- Recombinant Naja kaouthia Cobra venom factor protein (733-984AA)
-
亚型
- IgG
-
-
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
-
- Cobra Venom Factor,CVF
-
别名
- Cobra venom factor
-
背景
-
Background: Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity.
Aliases: antibody, Cobra venom factor antibody, CVF antibody, CVFk antibody, Complement C3 homolog) [Cleaved into: Cobra venom factor alpha chain, Cobra venom factor gamma chain, Cobra venom factor beta chain] antibody
-
UniProt
- Q91132
抗原
-
