MMP13 抗体 (AA 105-472)
Quick Overview for MMP13 抗体 (AA 105-472) (ABIN7177113)
抗原
See all MMP13 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 105-472
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交叉反应
- 小鼠
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Mouse Collagenase 3 protein (105-472AA)
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亚型
- IgG
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应用备注
- Recommended dilution: IHC:1:200-1:500,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))
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别名
- Mmp13
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背景
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Background: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.
Aliases: Mmp13 antibody, Collagenase 3 antibody, EC 3.4.24.- antibody, Matrix metalloproteinase-13 antibody, MMP-13 antibody
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UniProt
- P33435
抗原
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