YTHDC1 抗体 (AA 89-153)
Quick Overview for YTHDC1 抗体 (AA 89-153) (ABIN7175950)
抗原
See all YTHDC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 89-153
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交叉反应
- 人, 小鼠
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human YTH domain-containing protein 1 protein (89-153AA)
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亚型
- IgG
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anti-YTH Domain Containing 1 (YTHDC1) (AA 260-500) antibody
YTHDC1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-YTH Domain Containing 1 (YTHDC1) antibodyYTHDC1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-YTH Domain Containing 1 (YTHDC1) antibodyYTHDC1 适用: 人, 小鼠, 大鼠 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: WB:1:1000-1:5000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- YTHDC1 (YTH Domain Containing 1 (YTHDC1))
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别名
- YTHDC1
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背景
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Background: Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602).
Aliases: YTHDC1 antibody, KIAA1966 antibody, YT521 antibody, YTH domain-containing protein 1 antibody, Splicing factor YT521 antibody, YT521-B antibody
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UniProt
- Q96MU7
抗原
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