WDR61 抗体 (AA 2-305) (Biotin)
Quick Overview for WDR61 抗体 (AA 2-305) (Biotin) (ABIN7175779)
抗原
See all WDR61 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2-305
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交叉反应
- 人
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human WD repeat-containing protein 61 protein (2-305AA)
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亚型
- IgG
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anti-WD Repeat Domain 61 (WDR61) (AA 1-305) antibody
WDR61 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3E5-1A12 unconjugated
anti-WD Repeat Domain 61 (WDR61) (AA 1-305) antibodyWDR61 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-WD Repeat Domain 61 (WDR61) (AA 2-305) antibodyWDR61 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-WD Repeat Domain 61 (WDR61) (AA 1-305) antibodyWDR61 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-WD Repeat Domain 61 (WDR61) antibodyWDR61 适用: 人 WB, ChIP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- WDR61 (WD Repeat Domain 61 (WDR61))
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别名
- WDR61
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背景
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Background: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and \\\'Ser-2\\\'- and \\\'Ser-5\\\'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1, it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 \\\'Lys-4\\\' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of \\\'Lys-120\\\' of histone H2B (H2BK120ub1), UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3\\\' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 \\\'Lys-4\\\' (H3K4me3), dimethylation on histone H3 \\\'Lys-79\\\' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C.
Aliases: Meiotic recombination REC14 protein homolog antibody, REC14 antibody, Recombination protein REC14 antibody, Ski8 antibody, SKI8 homolog antibody, WD repeat containing protein 61 antibody, WD repeat domain 61 antibody, WD repeat-containing protein 61 antibody, WDR 61 antibody, wdr61 antibody, WDR61_HUMAN antibody
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UniProt
- Q9GZS3
抗原
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