WDR41 抗体 (AA 7-284) (HRP)
Quick Overview for WDR41 抗体 (AA 7-284) (HRP) (ABIN7175754)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 7-284
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human WD repeat-containing protein 41 protein (7-284AA)
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- WDR41 (WD Repeat Domain 41 (WDR41))
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别名
- WDR41
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背景
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Background: Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292).
Aliases: FLJ10904 antibody, MSTP048 antibody, WD repeat domain 41 antibody, WD repeat protein 41 antibody, WD repeat-containing protein 41 antibody, WDR 41 antibody, WDR41 antibody, WDR41_HUMAN antibody
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UniProt
- Q9HAD4
抗原
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