WIPI1 抗体 (AA 187-446)
Quick Overview for WIPI1 抗体 (AA 187-446) (ABIN7175707)
抗原
See all WIPI1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 187-446
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交叉反应
- 人, 小鼠
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human WD repeat domain phosphoinositide-interacting protein 1 protein (187-446AA)
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亚型
- IgG
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应用备注
- Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- WIPI1 (WD Repeat Domain, phosphoinositide Interacting 1 (WIPI1))
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别名
- WIPI1
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背景
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Background: Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.
Aliases: ATG 18 antibody, ATG18 antibody, Atg18 protein homolog antibody, ATG18A antibody, FLJ10055 antibody, WD repeat domain phosphoinositide interacting 1 antibody, WD repeat domain phosphoinositide interacting protein 1 antibody, WD repeat domain phosphoinositide-interacting protein 1 antibody, WD40 repeat protein interacting with phosphoinositides of 49 kDa antibody, WD40 repeat protein interacting with phosphoInositides of 49 kDa antibody, WIPI 1 alpha antibody, WIPI 1 antibody, WIPI 49 antibody, WIPI 49 kDa antibody, WIPI-1 antibody, wipi1 antibody, WIPI1_HUMAN antibody, WIPI49 antibody
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UniProt
- Q5MNZ9
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途径
- Nuclear Hormone Receptor Binding, ER-Nucleus Signaling
抗原
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