OTUB1 抗体 (AA 2-201)
Quick Overview for OTUB1 抗体 (AA 2-201) (ABIN7174393)
抗原
See all OTUB1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2-201
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Ubiquitin thioesterase OTUB1 protein (2-201AA)
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亚型
- IgG
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anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) antibody
OTUB1 适用: 人 WB, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 5B8 unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) antibodyOTUB1 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 5F7 unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) antibodyOTUB1 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 2H1 unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (Internal Region) antibodyOTUB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (AA 1-220) antibodyOTUB1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) antibodyOTUB1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (AA 1-271) antibodyOTUB1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C12 unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (Center) antibodyOTUB1 适用: 人, 小鼠 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (AA 1-271) antibodyOTUB1 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (AA 1-271) antibodyOTUB1 适用: 人 WB, IHC, ICC, IP, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))
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别名
- OTUB1
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背景
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Background: Hydrolase that can specifically remove \\\'Lys-48\\\'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of \\\'Lys-48\\\'-linked polyubiquitin chains, but not \\\'Lys-63\\\'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to \\\'Lys-48\\\'-linked ubiquitin. Plays a key non-catalytic role in DNA repair regulation by inhibiting activity of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of \\\'Lys-63\\\'-linked histone H2A and H2AX at DNA damage sites. Inhibits RNF168 independently of ubiquitin thioesterase activity by binding and inhibiting UBE2N/UBC13, the E2 partner of RNF168, thereby limiting spreading of \\\'Lys-63\\\'-linked histone H2A and H2AX marks. Inhibition occurs by binding to free ubiquitin: free ubiquitin acts as an allosteric regulator that increases affinity for UBE2N/UBC13 and disrupts interaction with UBE2V1. The OTUB1-UBE2N/UBC13-free ubiquitin complex adopts a configuration that mimics a cleaved \\\'Lys48\\\'-linked di-ubiquitin chain.
Aliases: Deubiquitinating enzyme OTUB1 antibody, hOTU1 antibody, HSPC263 antibody, OTB1 antibody, OTU domain containing ubiquitin aldehyde binding protein 1 antibody, OTU domain, ubiquitin aldehyde binding 1 antibody, OTU domain-containing Ubal-binding protein 1 antibody, OTU domain-containing ubiquitin aldehyde-binding protein 1 antibody, OTU-domain Ubal-binding 1 antibody, OTU1 antibody, Otub1 antibody, OTUB1_HUMAN antibody, Otubain 1 antibody, Otubain-1 antibody, Ubiquitin specific processing protease OTUB1 antibody, Ubiquitin thioesterase OTUB1 antibody, ubiquitin-specific protease otubain 1 antibody, Ubiquitin-specific-processing protease OTUB1 antibody
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UniProt
- Q96FW1
抗原
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