USP3 抗体 (C-Term)
Quick Overview for USP3 抗体 (C-Term) (ABIN7174308)
抗原
See all USP3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 101-400, C-Term
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交叉反应
- 人, 小鼠
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Ubiquitin carboxyl-terminal hydrolase 30 protein (101-400AA)
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亚型
- IgG
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应用备注
- Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- USP3 (Ubiquitin Specific Peptidase 3 (USP3))
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别名
- USP3
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背景
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Background: Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PARK2): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin\\\'s ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves \\\'Lys-6\\\'- and \\\'Lys-11\\\'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at \\\'Ser-65\\\' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).
Aliases: Deubiquitinating enzyme 30 antibody, FLJ40511 antibody, Ub-specific protease 30 antibody, Ubiquitin carboxyl terminal hydrolase 30 antibody, Ubiquitin carboxyl-terminal hydrolase 30 antibody, Ubiquitin specific peptidase 30 antibody, Ubiquitin specific processing protease 30 antibody, Ubiquitin thioesterase 30 antibody, Ubiquitin thiolesterase 30 antibody, Ubiquitin-specific-processing protease 30 antibody, UBP30_HUMAN antibody, usp30 antibody
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UniProt
- Q70CQ3
抗原
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